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Anti-TLE1/2/3/4 Antibody

Boster Bio Anti-TLE1/2/3/4 Antibody catalog # A02460. Tested in WB, ELISA, IHC applications. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Synonyms

Transducin-like enhancer protein 1; E (Sp1) homolog; Enhancer of split groucho-like protein 1; ESG1; TLE1

Gene Name

TLE1

UniProt

Q04724

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

The antiserum was produced against synthesized peptide derived from the C-terminal region of human TLE1/TLE2/TLE3/TLE4. AA range:721-770

Tissue Specificity

In all tissues examined, mostly in brain, liver and muscle.

Applications

WB, ELISA, IHC

Purification

Immunogen affinity purified

Concentration

1 mg/mL

Form

Liquid

Function

Transcriptional corepressor that binds to a number of transcription factors. Inhibits NF-kappa-B-regulated gene expression. Inhibits the transcriptional activation mediated by FOXA2, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Unusual function as coactivator for ESRRG. .

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Observed Molecular Weight

83201 MW

Gene Name Synonym

Transducin-like enhancer protein 1

Subcellular Location

Nucleus . Nuclear and chromatin-associated, depending on isoforms and phosphorylation status. Hyperphosphorylation decreases the affinity for nuclear components.

Contents

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

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