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Anti-PLCE1 Antibody

Boster Bio Anti-PLCE1 Antibody catalog # A02360. Tested in IHC, IF applications. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Synonyms

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1;3.1.4.11; Pancreas-enriched phospholipase C; Phosphoinositide phospholipase C-epsilon-1; Phospholipase C-epsilon-1; PLC-epsilon-1; PLCE1; KIAA1516, PLCE, PPLC

Gene Name

PLCE1

UniProt

Q9P212

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

Synthesized peptide derived from part region of human protein

Clonality

Polyclonal

Tissue Specificity

Widely expressed. Isoform 1 is broadly expressed and only absent in peripheral blood leukocytes. Isoform 2 is specifically expressed in placenta, lung and spleen.

Applications

IHC, IF

Purification

PLCE1 antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

1 mg/mL

Form

Liquid

Function

The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. PLCE1 is a bifunctional enzyme which also regulates small GTPases of the Ras superfamily through its Ras guanine- exchange factor (RasGEF) activity. As an effector of heterotrimeric and small G-protein, it may play a role in cell survival, cell growth, actin organization and T-cell activation.

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Observed Molecular Weight

258715 MW

Gene Name Synonym

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1

Subcellular Location

Cytoplasm, cytosol. Cell membrane. Golgi apparatus membrane. Recruited to plasma membrane by activated HRAS and RAP2. Recruited to perinuclear membrane by activated RAP1A. Isoform 1 and isoform 2 associates with Golgi membranes.

Protein Name

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1

Isotype

IgG

Contents

Liquid form in PBS containing 50% glycerol, and 0.02% sodium azide.

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