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Anti-PIK3C3 Antibody

Boster Bio Anti-PIK3C3 Antibody (Catalog # A02356) . Tested in ELISA, WB applications. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Background

PI 3-kinase p100 (phosphoinositide-3-kinase p100 subunit), also known as hVps34 or PIK3C3 (phosphoinositide-3-kinase class III), is a member of the PI3/PI4-kinase family (1) . It is a catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate and ubiquitously expressed with a highest expression in skeletal muscle (1,2) . PIK3C3 is involved in the endosome to lysosome transport and plays important roles in intracellular membrane trafficking and autophagy (3-5) .

Synonyms

VPS34, hVps34, VPS34, Phosphatidylinositol 3-kinase catalytic subunit type 3, Phosphatidylinositol 3-kinase p100 subunit, PI3-kinase type 3

Gene Name

PIK3C3

UniProt

Q8NEB9

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

PIK3C3 antibody is human, mouse and rat reactive.

Immunogen

PIK3C3 antibody was raised against an 18 amino acid peptide near the amino terminus of human PIK3C3. The immunogen is located within amino acids 130 - 180 of PIK3C3.

Clonality

Polyclonal

Tissue Specificity

Ubiquitously expressed, with a highest expression in skeletal muscle.

Applications

ELISA, WB

Field of Research

Autophagy

Purification

PIK3C3 antibody is affinity chromatography purified via peptide column.

Concentration

1 mg/mL

Form

Liquid

Function

Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2 (PubMed:20643123, PubMed:20208530) . Involved in the transport of lysosomal enzyme precursors to lysosomes. Required for transport from early to late endosomes (By similarity) .

Storage Conditions

PIK3C3 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Observed Molecular Weight

101549 MW

Gene Name Synonym

Phosphatidylinositol 3-kinase, catalytic subunit type 3

Subcellular Location

Midbody

Prediction Reactivity

Pig

Protein Name

Phosphatidylinositol 3-kinase, catalytic subunit type 3

Isotype

IgG

Contents

PIK3C3 antibody is supplied in PBS containing 0.02% sodium azide.

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