Anti-Catenin-Delta 1 (phospho-Y228) CTNND1 Antibody
Boster Bio Anti-Catenin-Delta 1 (phospho-Y228) CTNND1 Antibody catalog # A02333Y228. Tested in WB applications. This antibody reacts with Human, Mouse, Rat.
Product Specifications
Synonyms
Catenin delta-1; Cadherin-associated Src substrate; CAS; p120 catenin; p120 (ctn) ; p120 (cas) ; CTNND1; KIAA0384
Gene Name
CTNND1
UniProt
O60716
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Synthetic phosphopeptide derived from human Catenin-δ1 around the phosphorylation site of Tyrosine 228
Clonality
Polyclonal
Tissue Specificity
Expressed in vascular endothelium. Melanocytes and melanoma cells primarily express the long isoform 1A, whereas keratinocytes express shorter isoforms, especially 3A. The shortest isoform 4A, is detected in normal keratinocytes and melanocytes, and generally lost from cells derived from squamous cell carcinomas or melanomas. The C-terminal alternatively spliced exon B is present in the p120ctn transcripts in the colon, intestine and prostate, but lost in several tumor tissues derived from these organs.
Applications
WB
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Concentration
1 mg/mL
Form
Liquid
Function
Binds to and inhibits the transcriptional repressor ZBTB33, which may lead to activation of target genes of the Wnt signaling pathway (By similarity) . Associates with and regulates the cell adhesion properties of both C-, E- and N-cadherins, being critical for their surface stability. Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors. Promotes GLIS2 C-terminal cleavage.
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Observed Molecular Weight
108170 MW
Applications Notes
WB: 1:500-1:1000
Gene Name Synonym
Catenin delta-1
Subcellular Location
Cytoplasm
Protein Name
Catenin delta-1
Contents
Rabbit IgG, 1mg/mL in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
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