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Anti-HUMAN-CTNND1_isform 2ABC (Y174) Antibody

Boster Bio Anti-HUMAN-CTNND1_isform 2ABC (Y174) Antibody (Catalog # A02333) . Tested in WB application (s) . This antibody reacts with Human.

Product Specifications

Background

Binds to and inhibits the transcriptional repressor ZBTB33, which may lead to activation of target genes of the Wnt signaling pathway (By similarity) . Associates with and regulates the cell adhesion properties of both C-, E- and N-cadherins, being critical for their surface stability. Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors. Promotes GLIS2 C-terminal cleavage.

Synonyms

Catenin delta-1, Cadherin-associated Src substrate, CAS, p120 catenin, p120 (ctn), p120 (cas), CTNND1, KIAA0384

Gene Name

CTNND1

UniProt

O60716

Host

Rabbit

Reactivity

Human

Immunogen

This antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 160-200 amino acids from human.

Clonality

Polyclonal

Tissue Specificity

Expressed in vascular endothelium. Melanocytes and melanoma cells primarily express the long isoform 1A, whereas keratinocytes express shorter isoforms, especially 3A. The shortest isoform 4A, is detected in normal keratinocytes and melanocytes, and generally lost from cells derived from squamous cell carcinomas or melanomas. The C-terminal alternatively spliced exon B is present in the p120ctn transcripts in the colon, intestine and prostate, but lost in several tumor tissues derived from these organs

Applications

WB

Field of Research

Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Function

1461005520371349102070852037134917344476

Storage Conditions

Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Observed Molecular Weight

108170 Da

Applications Notes

WB: 1:2000

Subcellular Location

Cell junction, adherens junction. Cytoplasm. Nucleus. Cell membrane Note=Interaction with GLIS2 promotes nuclear translocation (By similarity) . Detected at cell-cell contacts (PubMed:15240885, PubMed:17047063) . NANOS1 induces its translocation from sites of cell- cell contact to the cytoplasm (PubMed:17047063) . CDH1 enhances cell membrane localization (PubMed:15240885) . Isoforms 4A and 1AB are excluded from the nucleus (PubMed:11896187) {ECO:0000250|UniProtKB:P30999, ECO:0000269|PubMed:11896187, ECO:0000269|PubMed:15240885, ECO:0000269|PubMed:17047063} [Isoform 2A]: Nucleus

Isotype

Rabbit IgG

Contents

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.

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