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Anti-DIO2 Antibody (Center)

Boster Bio Anti-DIO2 Antibody (Center) (Catalog # A02249-1) . Tested in WB, Flow Cytometry, IHC-P application (s) . This antibody reacts with Human, Mouse.

Product Specifications

Background

DIO2 belongs to the iodothyronine deiodinase family. It activates thyroid hormone by converting the prohormone thyroxine (T4) by outer ring deiodination (ORD) to bioactive 3,3',5-triiodothyronine (T3) .

Synonyms

Type II iodothyronine deiodinase, 5DII, DIOII, Type 2 DI, Type-II 5'-deiodinase, DIO2, ITDI2, TXDI2

Gene Name

DIO2

UniProt

Q92813

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

This DIO2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 165-191 amino acids of human DIO2.

Clonality

Polyclonal

Tissue Specificity

Isoform 1 is expressed in the lung, trachea, kidney, heart, skeletal muscle, placenta, fetal brain and several regions of the adult brain (PubMed:8755651, PubMed:11165050) . Isoform 2 is expressed in the brain, heart, kidney and trachea (PubMed:11165050)

Applications

WB, Flow Cytometry, IHC-P

Field of Research

Cancer, Metabolism, Neuroscience, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Function

Responsible for the deiodination of T4 (3,5,3',5'- tetraiodothyronine) into T3 (3,5,3'-triiodothyronine) . Essential for providing the brain with appropriate levels of T3 during the critical period of development.

Storage Conditions

Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Observed Molecular Weight

30552 Da

Subcellular Location

Membrane; Single-pass membrane protein

Prediction Reactivity

Pig

Isotype

Rabbit IgG

Contents

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.

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