Anti-Nuclear RNA export factor 1 NXF1 Antibody
Boster Bio Anti-Nuclear RNA export factor 1 NXF1 Antibody catalog # A02137. Tested in WB applications. This antibody reacts with Human.
Product Specifications
Synonyms
Nuclear RNA export factor 1; Tip-associated protein; Tip-associating protein; mRNA export factor TAP; NXF1; TAP
Gene Name
NXF1
UniProt
Q9UBU9
Host
Rabbit
Reactivity
Human
Immunogen
Synthetic peptide, corresponding to amino acids 1-45 of Human NXF1
Clonality
Polyclonal
Tissue Specificity
Expressed ubiquitously.
Applications
WB
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE)
Concentration
1 mg/mL
Form
Liquid
Function
Involved in the nuclear export of mRNA species bearing retroviral constitutive transport elements (CTE) and in the export of mRNA from the nucleus to the cytoplasm (TAP/NFX1 pathway) (PubMed:10924507) . The NXF1-NXT1 heterodimer is involved in the export of HSP70 mRNA in conjunction with ALYREF/THOC4 and THOC5 components of the TREX complex (PubMed:18364396, PubMed:19165146, PubMed:9660949) . ALYREF/THOC4-bound mRNA is thought to be transferred to the NXF1-NXT1 heterodimer for export (PubMed:18364396, PubMed:19165146, PubMed:9660949) . Also involved in nuclear export of m6A-containing mRNAs: interaction between SRSF3 and YTHDC1 facilitates m6A-containing mRNA-binding to both SRSF3 and NXF1, promoting mRNA nuclear export (PubMed:28984244) .
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Observed Molecular Weight
70182 MW
Applications Notes
WB: 1:500-1:1000
Gene Name Synonym
Nuclear RNA export factor 1
Subcellular Location
Nucleus
Protein Name
Nuclear RNA export factor 1
Contents
Rabbit IgG, 1mg/mL in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
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