Anti-HIF1AN Antibody
Boster Bio Anti-HIF1AN Antibody catalog # A02116. Tested in WB, ICC/IF, IP applications. This antibody reacts with Human, Mouse, Rat.
Product Specifications
Synonyms
Hypoxia-inducible factor 1-alpha inhibitor;1.14.11.30;1.14.11.n4; Factor inhibiting HIF-1; FIH-1; Hypoxia-inducible factor asparagine hydroxylase; HIF1AN; FIH1
Gene Name
HIF1AN
UniProt
Q9NWT6
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant fusion protein of human HIF1AN/FIH1 (NP_060372.2) .
Clonality
Polyclonal
Applications
WB, ICC, IF, IP
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Concentration
1 mg/mL
Form
Liquid
Function
Hydroxylates HIF-1 alpha at 'Asn-803' in the C-terminal transactivation domain (CAD) . Functions as an oxygen sensor and, under normoxic conditions, the hydroxylation prevents interaction of HIF-1 with transcriptional coactivators including Cbp/p300- interacting transactivator. Involved in transcriptional repression through interaction with HIF1A, VHL and histone deacetylases. Hydroxylates specific Asn residues within ankyrin repeat domains (ARD) of NFKB1, NFKBIA, NOTCH1, ASB4, PPP1R12A and several other ARD-containing proteins. Also hydroxylates Asp and His residues within ARDs of ANK1 and TNKS2, respectively. Negatively regulates NOTCH1 activity, accelerating myogenic differentiation. Positively regulates ASB4 activity, promoting vascular differentiation.
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Observed Molecular Weight
40285 MW
Gene Name Synonym
Hypoxia-inducible factor 1-alpha inhibitor
Subcellular Location
Nucleus. Cytoplasm. Cytoplasm, perinuclear region. Mainly cytoplasmic localization, but interaction with NOTCH1 results in nuclear localization and interaction with ABPA3 results in perinuclear localization in macrophages.
Protein Name
Hypoxia-inducible factor 1-alpha inhibitor
Contents
Rabbit IgG, 1mg/mL in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
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