Anti-Apelin APLN Antibody

Expressed in the brain with highest levels in the frontal cortex, thalamus, hypothalamus and midbrain (PubMed:10617103) . Secreted by the mammary gland into the colostrum and the milk.

Endogenous ligand for the apelin receptor (APLNR) (PubMed:10525157) . Drives internalization of the apelin receptor (By similarity) . Apelin-36 dissociates more hardly than (pyroglu) apelin-13 from APLNR (By similarity) . Hormone involved in the regulation of cardiac precursor cell movements during gastrulation and heart morphogenesis (By similarity) . Has an inhibitory effect on cytokine production in response to T-cell receptor/CD3 cross-linking; the oral intake of apelin in the colostrum and the milk might therefore modulate immune responses in neonates (By similarity) . Plays a role in early coronary blood vessels formation (By similarity) . Mediates myocardial contractility in an ERK1/2-dependent manner (By similarity) . May also have a role in the central control of body fluid homeostasis by influencing vasopressin release and drinking behavior (By similarity) .