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Anti-SLC29A1 Antibody

Boster Bio Anti-SLC29A1 Antibody (Catalog # A02058) . Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human.

Product Specifications

Background

SLC29A1 is a member of the equilibrative nucleoside transporter family which plays a key role in nucleoside and nucleobase uptake for salvage pathways of nucleotide synthesis (1,2) . SLC29A1 is a transmembrane glycoprotein that localizes to the plasma and mitochondrial membranes and mediates the cellular uptake of nucleosides from the surrounding medium (3) . As a nucleoside transporter, SLC29A1 plays an important role in the uptake of nucleoside-based anti-cancer drugs; polymorphisms of point mutations in the gene encoding this protein may affect the efficacy of these drugs (4) .

Synonyms

Solute carrier family 29 member 1, Equilibrative nucleoside transporter 1, ENT1

Gene Name

SLC29A1

UniProt

Q99808

Host

Rabbit

Reactivity

Human

Cross Reactivity

SLC29A1 antibody is human specific. SLC29A1 antibody is predicted to not cross-react with other SLC29 proteins.

Immunogen

SLC29A1 antibody was raised against a 17 amino acid peptide near the center of human SLC29A1. The immunogen is located within amino acids 240 - 290 of SLC29A1.

Clonality

Polyclonal

Tissue Specificity

Detected in erythrocytes (at protein level) . Expressed in heart, brain, mammary gland, erythrocytes and placenta, and also in fetal liver and spleen.

Applications

ELISA, WB, IHC-P, IF

Field of Research

Cancer, Homeostasis

Purification

SLC29A1 antibody is affinity chromatography purified via peptide column.

Concentration

1 mg/mL

Form

Liquid

Function

Mediates both influx and efflux of nucleosides across the membrane (equilibrative transporter) . It is sensitive (ES) to low concentrations of the inhibitor nitrobenzylmercaptopurine riboside (NBMPR) and is sodium-independent. It has a higher affinity for adenosine. Inhibited by dipyridamole and dilazep (anticancer chemotherapeutics drugs) .

Storage Conditions

SLC29A1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Observed Molecular Weight

50219 MW

Gene Name Synonym

Solute carrier family 29 (equilibrative nucleoside transporter), member 1

Subcellular Location

Basolateral cell membrane; Multi-pass membrane protein. Apical cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Predominantly localized in the basolateral membrane in polarized MDCK cells.

Prediction Reactivity

Rat, Mouse

Protein Name

Solute carrier family 29 (equilibrative nucleoside transporter), member 1

Isotype

IgG

Contents

SLC29A1 antibody is supplied in PBS containing 0.02% sodium azide.

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