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Anti-PROX-1-S514 Antibody

Boster Bio Anti-PROX-1-S514 Antibody (Catalog # A01985) . Tested in IHC-P, Flow Cytometry, WB application (s) . This antibody reacts with Human, Mouse.

Product Specifications

Background

Apolipoprotein H has been implicated in a variety of physiologic pathways including lipoprotein metabolism, coagulation, and the production of antiphospholipid autoantibodies. APOH may be a required cofactor for anionic phospholipid binding by the antiphospholipid autoantibodies found in sera of many patients with lupus and primary antiphospholipid syndrome, but it does not seem to be required for the reactivity of antiphospholipid autoantibodies associated with infections.

Synonyms

Prospero homeobox protein 1, Homeobox prospero-like protein PROX1, PROX-1, PROX1

Gene Name

PROX1

UniProt

Q92786

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

This PROX1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 492-520 amino acids from human PROX1.

Clonality

Polyclonal

Tissue Specificity

Most actively expressed in the developing lens. Detected also in embryonic brain, lung, liver and kidney. In adult, it is more abundant in heart and liver than in brain, skeletal muscle, kidney and pancreas.

Applications

IHC-P, Flow Cytometry, WB

Field of Research

Cardiovascular, Neuroscience

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Function

Transcription factor involved in developmental processes such as cell fate determination, gene transcriptional regulation and progenitor cell regulation in a number of organs. Plays a critical role in embryonic development and functions as a key regulatory protein in neurogenesis and the development of the heart, eye lens, liver, pancreas and the lymphatic system. Involved in the regulation of the circadian rhythm. Represses: transcription of the retinoid-related orphan receptor RORG, transcriptional activator activity of RORA and RORG and the expression of RORA/G-target genes including core clock components: BMAL1, NPAS2 and CRY1 and metabolic genes: AVPR1A and ELOVL3.

Storage Conditions

Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Observed Molecular Weight

83203 Da

Subcellular Location

Nucleus {ECO:0000250|UniProtKB:P48437}. Note=RORG promotes its nuclear localization. {ECO:0000250|UniProtKB:P48437}

Isotype

Rabbit IgG

Contents

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.

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