Anti-LEDGF PSIP1 Monoclonal Antibody
Boster Bio Anti-LEDGF PSIP1 Monoclonal Antibody catalog # A01960. Tested in WB, IHC, IF, ELISA applications. This antibody reacts with Human, Rat, Monkey.
Product Specifications
Synonyms
PC4 and SFRS1-interacting protein; CLL-associated antigen KW-7; Dense fine speckles 70 kDa protein; DFS 70; Lens epithelium-derived growth factor; Transcriptional coactivator p75/p52; PSIP1; DFS70, LEDGF, PSIP2
Gene Name
PSIP1
UniProt
O75475
Host
Mouse
Reactivity
Human, Rat, Monkey
Immunogen
Purified recombinant fragment of human LEDGF expressed in E. Coli.
Clonality
Monoclonal
Clone
Clone: 11168
Tissue Specificity
Widely expressed. Expressed at high level in the thymus. Expressed in fetal and adult brain. Expressed in neurons, but not astrocytes. Markedly elevated in fetal as compared to adult brain. In the adult brain, expressed in the subventricular zone (SVZ), in hippocampus, and undetectable elsewhere. In the fetal brain, expressed in the germinal neuroepithelium and cortical plate regions. .
Applications
WB, IHC, IF, ELISA
Purification
Ascitic fluid
Concentration
1 mg/mL
Form
Liquid
Function
Transcriptional coactivator involved in neuroepithelial stem cell differentiation and neurogenesis. Involved in particular in lens epithelial cell gene regulation and stress responses. May play an important role in lens epithelial to fiber cell terminal differentiation. May play a protective role during stress-induced apoptosis. Isoform 2 is a more general and stronger transcriptional coactivator. Isoform 2 may also act as an adapter to coordinate pre-mRNA splicing. Cellular cofactor for lentiviral integration. .
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Observed Molecular Weight
60103 MW
Gene Name Synonym
PC4 and SFRS1-interacting protein
Subcellular Location
Nucleus . Remains chromatin-associated throughout the cell cycle.
Contents
Ascitic fluid containing 0.03% sodium azide.
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