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Anti-Histone deacetylase 8 HDAC8 Antibody

Boster Bio Anti-Histone deacetylase 8 HDAC8 Antibody catalog # A01843. Tested in WB, ICC/IF, IHC, IP, Flow Cytometry applications. This antibody reacts with Human.

Product Specifications

Synonyms

Histone deacetylase 8; HD8;3.5.1.98; HDAC8; HDACL1; CDA07

Gene Name

HDAC8

UniProt

Q9BY41

Host

Rabbit

Reactivity

Human

Immunogen

Recombinant protein

Clonality

Polyclonal

Tissue Specificity

Weakly expressed in most tissues. Expressed at higher level in heart, brain, kidney and pancreas and also in liver, lung, placenta, prostate and kidney.

Applications

WB, ICC, IF, IHC, IP, Flow Cytometry

Purification

ProA affinity purified

Concentration

1 mg/mL

Form

Liquid

Function

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) . Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Also involved in the deacetylation of cohesin complex protein SMC3 regulating release of cohesin complexes from chromatin. May play a role in smooth muscle cell contractility.

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Observed Molecular Weight

41758 MW

Gene Name Synonym

Histone deacetylase 8

Subcellular Location

Nucleus. Cytoplasm. Excluded from the nucleoli. Found in the cytoplasm of cells showing smooth muscle differentiation.

Protein Name

Histone deacetylase 8

Contents

Rabbit IgG, 1mg/mL in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

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