Anti-Mouse Ring1 Antibody (C-term)
Boster Bio Anti-Mouse Ring1 Antibody (C-term) (Catalog # A01824) . Tested in WB application (s) . This antibody reacts with Mouse.
Product Specifications
Background
Constitutes one of the E3 ubiquitin-protein ligases that mediate monoubiquitination of 'Lys-119' of histone H2A, thereby playing a central role in histone code and gene regulation. H2A 'Lys-119' ubiquitination gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility. Compared to RNF2/RING2, it does not have the main E3 ubiquitin ligase activity on histone H2A, and it may rather act as a modulator of RNF2/RING2 activity (By similarity) .
Synonyms
E3 ubiquitin-protein ligase RING1, 632-, Polycomb complex protein RING1, RING finger protein 1, Transcription repressor Ring1A, Ring1, Ring1A, Rnf1
Gene Name
Ring1
UniProt
O35730
Host
Rabbit
Reactivity
Mouse
Immunogen
This Mouse Ring1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 306-340 amino acids from the C-terminal region of human Mouse Ring1.
Clonality
Polyclonal
Applications
WB
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Function
Constitutes one of the E3 ubiquitin-protein ligases that mediate monoubiquitination of 'Lys-119' of histone H2A, thereby playing a central role in histone code and gene regulation. H2A 'Lys-119' ubiquitination gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility. Compared to RNF2/RING2, it does not have the main E3 ubiquitin ligase activity on histone H2A, and it may rather act as a modulator of RNF2/RING2 activity (By similarity) .
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Observed Molecular Weight
42631 Da
Applications Notes
WB: 1:1000
Subcellular Location
Nucleus speckle.
Isotype
Rabbit IgG
Contents
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.
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