Anti-AKR1C3 Antibody
Boster Bio Anti-AKR1C3 Antibody catalog # A01820. Tested in WB, ICC/IF, IP applications. This antibody reacts with Human, Mouse.
Product Specifications
Synonyms
Aldo-keto reductase family 1 member C3;1.-.-.-;17-beta-hydroxysteroid dehydrogenase type 5;17-beta-HSD 5;3-alpha-HSD type II, brain;3-alpha-hydroxysteroid dehydrogenase type 2;3-alpha-HSD type 2;1.1.1.357
Gene Name
AKR1C3
UniProt
P42330
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
Recombinant fusion protein of human AKR1C3 (NP_003730.4) .
Clonality
Polyclonal
Tissue Specificity
Expressed in many tissues including adrenal gland, brain, kidney, liver, lung, mammary gland, placenta, small intestine, colon, spleen, prostate and testis. The dominant HSD in prostate and mammary gland. In the prostate, higher levels in epithelial cells than in stromal cells. In the brain, expressed in medulla, spinal cord, frontotemporal lobes, thalamus, subthalamic nuclei and amygdala. Weaker expression in the hippocampus, substantia nigra and caudate.
Applications
WB, ICC, IF, IP
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Concentration
1 mg/mL
Form
Liquid
Function
Catalyzes the conversion of aldehydes and ketones to alcohols. Catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ) and the oxidation of 9-alpha,11-beta- PGF2 to PGD2. Functions as a bi-directional 3-alpha-, 17-beta- and 20-alpha HSD. Can interconvert active androgens, estrogens and progestins with their cognate inactive metabolites. Preferentially transforms androstenedione (4-dione) to testosterone.
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Observed Molecular Weight
36853 MW
Gene Name Synonym
Aldo-keto reductase family 1 member C3
Subcellular Location
Cytoplasm.
Protein Name
Aldo-keto reductase family 1 member C3
Contents
Rabbit IgG, 1mg/mL in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
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