Anti-Axin-2 AXIN2 Antibody
Boster Bio Anti-Axin-2 AXIN2 Antibody (Catalog # A01772) . Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.
Product Specifications
Background
Like the related protein AXIN1, AXIN2 is thought to play an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway. In mouse, AXIN2 organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and AXIN2, which leads to the degradation of beta-catenin, which is thought to be an important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair.
Synonyms
AXIL, ODCRCS, Axin-2, Axin-like protein, Axil
Gene Name
AXIN2
UniProt
Q9Y2T1
Host
Rabbit
Reactivity
Human, Mouse, Rat
Cross Reactivity
AXIN2 antibody is predicted to not cross-react with AXIN1. At least four isoforms of AXIN2 are known to exist; this antibody will recognize all four.
Immunogen
AXIN2 antibody was raised against a 20 amino acid synthetic peptide near the carboxy terminus of human AXIN2. The immunogen is located within amino acids 780 - 830 of AXIN2.
Clonality
Polyclonal
Tissue Specificity
Expressed in brain and lymphoblast.
Applications
ELISA, WB, IHC-P, IF
Field of Research
Cancer, Cell Cycle
Purification
AXIN2 Antibody is affinity chromatography purified via peptide column.
Concentration
1 mg/mL
Form
Liquid
Function
Inhibitor of the Wnt signaling pathway. Down-regulates beta-catenin. Probably facilitate the phosphorylation of beta- catenin and APC by GSK3B (By similarity) . .
Storage Conditions
AXIN2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Observed Molecular Weight
93558 MW
Gene Name Synonym
Axin 2
Subcellular Location
Cytoplasm.
Prediction Reactivity
Chicken
Protein Name
Axin 2
Isotype
IgG
Contents
AXIN2 Antibody is supplied in PBS containing 0.02% sodium azide.
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