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Anti-HBEGF Antibody

Boster Bio Anti-HBEGF Antibody catalog # A01759. Tested in WB, ELISA applications. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Synonyms

Proheparin-binding EGF-like growth factor; Heparin-binding EGF-like growth factor; HB-EGF; HBEGF; Diphtheria toxin receptor; DT-R; HBEGF; DTR, DTS, HEGFL

Gene Name

HBEGF

UniProt

Q99075

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

Synthesized peptide derived from human protein at AA range: 130-210

Clonality

Polyclonal

Applications

WB, ELISA

Purification

HBEGF antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

1 mg/mL

Form

Liquid

Function

Growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. Required for normal cardiac valve formation and normal heart function. Promotes smooth muscle cell proliferation. May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts, but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Also acts as a diphtheria toxin receptor.

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Observed Molecular Weight

23067 MW

Gene Name Synonym

Proheparin-binding EGF-like growth factor

Subcellular Location

Heparin-binding EGF-like growth factor: Secreted, extracellular space. Mature HB-EGF is released into the extracellular space and probably binds to a receptor.

Protein Name

Proheparin-binding EGF-like growth factor

Isotype

IgG

Contents

Liquid form in PBS containing 50% glycerol, and 0.02% sodium azide.

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