L-Buthionine-(S,R)-sulfoximine
Product Specifications
UNSPSC Description
L-Buthionine-(S,R)-sulfoximine is a cell-permeable, potent, fast acting and irreversible inhibitor of g-glutamylcysteine synthetase and depletes cellular glutathione levels. The IC50 value of L-Buthionine-(S,R)-sulfoximine on melanoma, breast and ovarian tumor specimens are 1.9 μM, 8.6 μM, and 29 μM, respectively.
Target Antigen
Ferroptosis
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/L-Buthionine-_S,R_-sulfoximine.html
Purity
99.94
Solubility
DMSO : < 1 mg/mL (ultrasonic)|H2O : 18.33 mg/mL (ultrasonic)
Smiles
N[C@H](C(O)=O)CCS(CCCC)(=O)=N
Molecular Weight
222.31
References & Citations
[1]Fruehauf JP, et al. Selective and synergistic activity of L-S,R-buthionine sulfoximine on malignant melanoma is accompanied by decreased expression of glutathione-S-transferase. Pigment Cell Res. 1997 Aug;10(4):236-49.|[2]Reliene R, et al. Glutathione depletion by buthionine sulfoximine induces DNA deletions in mice. Carcinogenesis. 2006 Feb;27(2):240-4.|[3]Satoru Nishizawa, et al. Low tumor glutathione level as a sensitivity marker for glutamate-cysteine ligase inhibitors. Oncol Lett. 2018 Jun;15(6):8735-8743.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-106376A/L-Buthionine-S-R-sulfoximine-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-106376A/L-Buthionine-S-R-sulfoximine-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
83730-53-4
Available Sizes
Curated Selection
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