Anti-DDR2/Tyro10 Antibody
Boster Bio Anti-DDR2/Tyro10 Antibody catalog # A01698. Tested in IF, IHC, ELISA applications. This antibody reacts with Human, Mouse.
Product Specifications
Synonyms
Discoidin domain-containing receptor 2; Discoidin domain receptor 2;2.7.10.1; CD167 antigen-like family member B; Discoidin domain-containing receptor tyrosine kinase 2; Neurotrophic tyrosine kinase, receptor-related 3; Receptor protein-tyrosine kinase TKT; Tyrosine-protein kinase TYRO10; CD167b; DDR2; NTRKR3, TKT, TYRO10
Gene Name
DDR2
UniProt
Q16832
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
Synthetic peptide from human protein at AA range: 31-80
Tissue Specificity
Detected in osteocytes, osteoblastic cells in subchondral bone, bone lining cells, tibia and cartilage (at protein level) . Detected at high levels in heart and lung, and at low levels in brain, placenta, liver, skeletal muscle, pancreas, and kidney. .
Applications
IF, IHC, ELISA
Purification
Immunogen affinity purified
Concentration
1 mg/mL
Form
Liquid
Function
Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell differentiation, remodeling of the extracellular matrix, cell migration and cell proliferation. Required for normal bone development. Regulates osteoblast differentiation and chondrocyte maturation via a signaling pathway that involves MAP kinases and leads to the activation of the transcription factor RUNX2. Regulates remodeling of the extracellular matrix by up-regulation of the collagenases MMP1, MMP2 and MMP13, and thereby facilitates cell migration and tumor cell invasion. Promotes fibroblast migration and proliferation, and thereby contributes to cutaneous wound healing. .
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Observed Molecular Weight
96736 MW
Gene Name Synonym
Discoidin domain-containing receptor 2
Subcellular Location
Cell membrane ; Single- pass type I membrane protein .
Isotype
IgG
Contents
PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol.
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