Anti-GDF-15 Antibody
Boster Bio Anti-GDF-15 Antibody catalog # A01583. Tested in WB, IHC, ICC/IF, IP applications. This antibody reacts with Human, Mouse, Rat.
Product Specifications
Synonyms
Growth/differentiation factor 15 ; GDF-15 ; Macrophage inhibitory cytokine 1 ; MIC-1
Gene Name
GDF15
UniProt
Q99988
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant fusion protein of human GDF15 (NP_004855.2) .
Clonality
Polyclonal
Tissue Specificity
Highly expressed in placenta, with lower levels in prostate and colon and some expression in kidney (PubMed:9348093) . Detected in plasma (at protein level) (PubMed:28572090, PubMed:29046435) .
Applications
WB, IHC, ICC, IF, IP
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Concentration
1 mg/mL
Form
Liquid
Function
Regulates food intake, energy expenditure and body weight in response to metabolic and toxin-induced stresses (PubMed:28953886, PubMed:28846097, PubMed:28846098, PubMed:28846099, PubMed:23468844, PubMed:29046435) . Binds to its receptor, GFRAL, and activates GFRAL-expressing neurons localized in the area postrema and nucleus tractus solitarius of the brainstem (PubMed:28953886, PubMed:28846097, PubMed:28846098, PubMed:28846099) . It then triggers the activation of neurons localized within the parabrachial nucleus and central amygdala, which contitutes part of the 'emergency circuit' that shapes feeding responses to stressful conditions (PubMed:28953886) . On hepatocytes, inhibits growth hormone signaling (By similarity) .
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Observed Molecular Weight
34140 MW
Gene Name Synonym
Growth/differentiation factor 15
Subcellular Location
Secreted
Protein Name
Growth/differentiation factor 15
Contents
Rabbit IgG, 1mg/mL in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
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