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Anti-Protein phosphatase 1D PPM1D Antibody

Boster Bio Anti-Protein phosphatase 1D PPM1D Antibody (Catalog # A01576) . Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Background

Wild-type p53 induced phosphatase 1 (WIP1) / protein phosphatase magnesium-dependent 1 delta (PPM1D), a protein identified in the p53 DNA response pathway, is a member of the PP2C family of serine/threonine protein phosphatases which selectively inactivates p38 MAPK and dephosphorylates the ATM/ATR targets, Chk1 and p53 (1,2) . Studies have shown that it is overexpressed in human cancers and is involved in the regulation of multiple DNA damage signaling pathways (2,3) . PPM1D deletion results in a reduction of T and B cell function and compromised cell division, rendering cells resistant to becoming cancerous and slowing tumor development (4,5) .

Synonyms

Protein phosphatase Mg2+/Mn2+ dependent 1D, p53-induced protein phosphatase 1, PP2C-DELTA, Protein phosphatase 1D, WIP1

Gene Name

PPM1D

UniProt

Q8IVR6

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

PPM1D antibody is human, mouse and rat reactive. At least two isoforms of PPM1D are known to exist; this antibody will only detect the larger isoform.

Immunogen

PPM1D antibody was raised against an 18 amino acid peptide near the carboxy terminus of human PPM1D. The immunogen is located within the last 50 amino acids of PPM1D.

Clonality

Polyclonal

Applications

ELISA, WB, IHC-P, IF

Field of Research

Cancer, Cell Cycle

Purification

PPM1D antibody is affinity chromatography purified via peptide column.

Concentration

1 mg/mL

Form

Liquid

Storage Conditions

PPM1D antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Gene Name Synonym

Protein phosphatase Mg2+/Mn2+ dependent 1D

Protein Name

Protein phosphatase Mg2+/Mn2+ dependent 1D

Isotype

IgG

Contents

PPM1D antibody is supplied in PBS containing 0.02% sodium azide.

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