Anti-BIN1 Antibody

Myc box-dependent-interacting protein 1; Amphiphysin II; Amphiphysin-like protein; Box-dependent myc-interacting protein 1; Bridging integrator 1; BIN1; AMPHL

Ubiquitous. Highest expression in the brain and muscle (PubMed:9182667) . Expressed in oligodendrocytes (PubMed:27488240) . Isoform IIA is expressed only in the brain, where it is detected in the gray matter, but not in the white matter (PubMed:27488240) . Isoform BIN1 is widely expressed with highest expression in skeletal muscle.

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Is a key player in the control of plasma membrane curvature, membrane shaping and membrane remodeling. Required in muscle cells for the formation of T-tubules, tubular invaginations of the plasma membrane that function in depolarization-contraction coupling (PubMed:24755653) . Is a negative regulator of endocytosis (By similarity) . Is also involved in the regulation of intracellular vesicles sorting, modulation of BACE1 trafficking and the control of amyloid-beta production (PubMed:27179792) . In neuronal circuits, endocytosis regulation may influence the internalization of PHF-tau aggregates (By similarity) . May be involved in the regulation of MYC activity and the control cell proliferation (PubMed:8782822) . Has actin bundling activity and stabilizes actin filaments against depolymerization in vitro (PubMed:28893863) .