Anti-Cofilin (phospho-S3) CFL1 Antibody
Boster Bio Anti-Cofilin (phospho-S3) CFL1 Antibody catalog # A01525S3. Tested in WB, IHC applications. This antibody reacts with Human.
Product Specifications
Synonyms
Cofilin-1;18 kDa phosphoprotein; p18; Cofilin, non-muscle isoform; CFL1; CFL
Gene Name
CFL1
UniProt
P23528
Host
Rabbit
Reactivity
Human
Immunogen
Synthetic phosphopeptide derived from human Cofilin 1 around the phosphorylation site of Serine 3.
Clonality
Polyclonal
Tissue Specificity
Widely distributed in various tissues.
Applications
WB, IHC
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Concentration
1 mg/mL
Form
Liquid
Function
Binds to F-actin and exhibits pH-sensitive F-actin depolymerizing activity. Regulates actin cytoskeleton dynamics. Important for normal progress through mitosis and normal cytokinesis. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required for the up-regulation of atypical chemokine receptor ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation (PubMed:11812157, PubMed:15580268, PubMed:21834987, PubMed:23633677) . Required for neural tube morphogenesis and neural crest cell migration (By similarity) .
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Observed Molecular Weight
18502 MW
Gene Name Synonym
Cofilin-1
Subcellular Location
Nucleus matrix
Protein Name
Cofilin-1
Contents
Rabbit IgG, 1mg/mL in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
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