Anti-ERCC6 Antibody
Boster Bio Anti-ERCC6 Antibody catalog # A01519. Tested in WB applications. This antibody reacts with Human, Mouse, Rat.
Product Specifications
Synonyms
DNA excision repair protein ERCC-6;3.6.4.-; ATP-dependent helicase ERCC6; Cockayne syndrome protein CSB; ERCC6; CSB
Gene Name
ERCC6
UniProt
Q03468
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
A synthetic peptide corresponding to residues in Human ERCC6.
Clonality
Polyclonal
Applications
WB
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Concentration
1 mg/mL
Form
Liquid
Function
Essential factor involved in transcription-coupled nucleotide excision repair which allows RNA polymerase II-blocking lesions to be rapidly removed from the transcribed strand of active genes. Upon DNA-binding, it locally modifies DNA conformation by wrapping the DNA around itself, thereby modifying the interface between stalled RNA polymerase II and DNA. It is required for transcription-coupled repair complex formation. It recruits the CSA complex (DCX (ERCC8) complex), nucleotide excision repair proteins and EP300 to the at sites of RNA polymerase II- blocking lesions.
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Observed Molecular Weight
168416 MW
Applications Notes
WB: 1:500-1:1000
Gene Name Synonym
DNA excision repair protein ERCC-6
Subcellular Location
Nucleus
Protein Name
DNA excision repair protein ERCC-6
Contents
Rabbit IgG, 1mg/mL in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
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