Anti-ARHGEF5 Antibody
Boster Bio Anti-ARHGEF5 Antibody catalog # A01487. Tested in WB applications. This antibody reacts with Human, Mouse, Rat.
Product Specifications
Synonyms
Rho guanine nucleotide exchange factor 5; Ephexin-3; Guanine nucleotide regulatory protein TIM; Oncogene TIM; Transforming immortalized mammary oncogene; p60 TIM; ARHGEF5; TIM
Gene Name
ARHGEF5
UniProt
Q12774
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Synthetic peptide, corresponding to amino acids 1310-1355 of Human ARHGEF5.
Clonality
Polyclonal
Tissue Specificity
Ubiquitously expressed with highest levels in placenta. High levels are also found in colon, kidney, trachea, prostate, liver, pancreas, pituitary gland, thyroid gland and mammary gland. In fetal tissues, expressed at high levels in kidney, lung and liver (PubMed:15601624) . Expressed at low levels in lung and heart (PubMed:14662653) .
Applications
WB
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Concentration
1 mg/mL
Form
Liquid
Function
Guanine nucleotide exchange factor which activates Rho GTPases (PubMed:15601624) . Strongly activates RHOA (PubMed:15601624) . Also strongly activates RHOB, weakly activates RHOC and RHOG and shows no effect on RHOD, RHOV, RHOQ or RAC1 (By similarity) . Involved in regulation of cell shape and actin cytoskeletal organization (PubMed:15601624) . Plays a role in actin organization by generating a loss of actin stress fibers and the formation of membrane ruffles and filopodia (PubMed:14662653) . Required for SRC-induced podosome formation (By similarity) . Involved in positive regulation of immature dendritic cell migration (By similarity) .
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Observed Molecular Weight
176799 MW
Applications Notes
WB: 1:500-1:1000
Gene Name Synonym
Rho guanine nucleotide exchange factor 5
Subcellular Location
Cytoplasm
Protein Name
Rho guanine nucleotide exchange factor 5
Contents
Rabbit IgG, 1mg/mL in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
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