Anti-Phospho-CDC25A (T507) Antibody
Boster Bio Anti-Phospho-CDC25A (T507) Antibody (Catalog # A01433-2) . Tested in IF, WB, IHC-P application (s) . This antibody reacts with Human.
Product Specifications
Background
CDC25A is a member of the CDC25 family of phosphatases. CDC25A is required for progression from G1 to the S phase of the cell cycle. It activates the cyclin-dependent kinase CDC2 by removing two phosphate groups. CDC25A is specifically degraded in response to DNA damage, which prevents cells with chromosomal abnormalities from progressing through cell division. CDC25A is an oncogene, although its exact role in oncogenesis has not been demonstrated. Two transcript variants encoding different isoforms have been found for this gene.
Synonyms
M-phase inducer phosphatase 1, Dual specificity phosphatase Cdc25A, CDC25A
Gene Name
CDC25A
UniProt
P30304
Host
Rabbit
Reactivity
Human
Immunogen
This CDC25A Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding T507 of human CDC25A.
Clonality
Polyclonal
Applications
IF, WB, IHC-P
Field of Research
Cancer, Cell Biology
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Function
Tyrosine protein phosphatase which functions as a dosage- dependent inducer of mitotic progression. Directly dephosphorylates CDK1 and stimulates its kinase activity. Also dephosphorylates CDK2 in complex with cyclin E, in vitro.
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Observed Molecular Weight
59087 Da
Prediction Reactivity
Bovine, Mouse, Rat
Isotype
Rabbit IgG
Contents
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.
Curated Selection
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