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Anti-PLB-T17 Antibody

Boster Bio Anti-PLB-T17 Antibody (Catalog # A01395) . Tested in Flow Cytometry, IHC-P, WB application (s) . This antibody reacts with Human, Mouse, Rat.

Product Specifications

Background

PLB is a 52 amino acid phosphoprotein which regulates the calcium pump of cardiac sarcoplasmic reticulum (SR) . PLB is an oligomer of five identical subunits each having a cytoplasmic and transmembrane domain. The cytoplasmic domain (residues 1 to 25) contains the phosphorylation sites and is highly basic and readily cleaved by proteases; whereas the transmembrane domain (residues 25 to 52) is mostly hydrophobic, protease resistant and stabilizes the pentamer.

Synonyms

Cardiac phospholamban, PLB, PLN, PLB

Gene Name

PLN

UniProt

P26678

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

This PLB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids of human PLB.

Clonality

Polyclonal

Tissue Specificity

Heart muscle (at protein level) .

Applications

Flow Cytometry, IHC-P, WB

Field of Research

Cardiovascular, Metabolism, Signal Transduction, Mitochondria

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Function

28890335

Storage Conditions

Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Observed Molecular Weight

6109 Da

Subcellular Location

Endoplasmic reticulum membrane; Single-pass membrane protein. Sarcoplasmic reticulum membrane; Single-pass membrane protein. Mitochondrion membrane {ECO:0000250|UniProtKB:A4IFH6}; Single-pass membrane protein. Membrane {ECO:0000250|UniProtKB:P61014}; Single-pass membrane protein. Note=Colocalizes with HAX1 at the endoplasmic reticulum (PubMed:17241641) . Colocalizes with DMPK a the sarcoplasmic reticulum (PubMed:15598648) .

Isotype

Rabbit IgG

Contents

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.

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