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Anti-MIB1 Antibody

Boster Bio Anti-MIB1 Antibody (Catalog # A01387) . Tested in ELISA, WB, ICC, IF applications. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Background

The E3 ubiquitin-protein ligase MIB1, also known as Mindbomb homolog 1, contains multiple ankyrin repeats and RING finger domains that functions as an E3 ubiquitin ligase (1) . MIB1 interacts with and regulates the cellular expression of the death-associated protein kinase 1 (DAPK1) protein by promoting its ubiquitination and degradation (1) . It also positively regulates Notch signaling by ubiquitinating the Notch receptors, thereby facilitating their endocytosis (2) .

Synonyms

MIB, DIP1, ZZZ6, DIP-1, LVNC7, ZZANK2, KIAA1323, E3 ubiquitin-protein ligase MIB1, DAPK-interacting protein 1

Gene Name

MIB1

UniProt

Q86YT6

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

MIB1 antibody is human, mouse and rat reactive. At least three isoforms of MIB1 are known to exist.

Immunogen

MIB1 antibody was raised against a 19 amino acid peptide near the carboxy terminus of human MIB1. The immunogen is located within amino acids 920 - 970 of MIB1.

Clonality

Polyclonal

Tissue Specificity

Widely expressed at low level. Expressed at higher level in spinal cord, ovary, whole brain, and all specific brain regions examined.

Applications

ELISA, WB, ICC, IF

Field of Research

Homeostasis, Apoptosis

Purification

MIB1 antibody is affinity chromatography purified via peptide column.

Concentration

1 mg/mL

Form

Liquid

Function

E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. Probably mediates ubiquitination and subsequent proteasomal degradation of DAPK1, thereby antagonizing anti-apoptotic effects of DAPK1 to promote TNF- induced apoptosis (By similarity) . Involved in ubiquitination of centriolar satellite CEP131, CEP290 and PCM1 proteins and hence inhibits primary cilium formation in proliferating cells. Mediates 'Lys-63'-linked polyubiquitination of TBK1, which probably participates in kinase activation.

Storage Conditions

MIB1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Observed Molecular Weight

110136 MW

Gene Name Synonym

Mindbomb E3 ubiquitin protein ligase 1

Subcellular Location

Cytoplasm

Protein Name

Mindbomb E3 ubiquitin protein ligase 1

Isotype

IgG

Contents

MIB1 Antibody is supplied in PBS containing 0.02% sodium azide.

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