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Anti-ME2 Antibody

Boster Bio Anti-ME2 Antibody (Catalog # A01380) . Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human.

Product Specifications

Background

ME2 is a homotetrameric, mitochondrial NAD-dependent malic enzyme that catalyzes the oxidative decarboxylation of malate to pyruvate (1) . It is related to malic enzyme 1 (ME1), a cytoplasmic NADP-dependent enzyme that generates NADPH for fatty acid biosynthesis (2) . The expression of both malic enzymes is reciprocally regulated by p53; this regulation has been shown to modulate metabolism and senescence (3) . Certain single-nucleotide polymorphism haplotypes of the ME2 gene have been shown to increase the risk for idiopathic generalized epilepsy (4) .

Synonyms

ODS1, NAD-dependent malic enzyme, mitochondrial, Malic enzyme 2, NAD-ME

Gene Name

ME2

UniProt

P23368

Host

Rabbit

Reactivity

Human

Cross Reactivity

ME2 antibody is human specific. At least two isoforms of ME2 are known to exist; this antibody will detect both isoforms. ME2 antibody is predicted not to cross-react with ME1.

Immunogen

ME2 antibody was raised against a 17 amino acid peptide near the center of human ME2. The immunogen is located within amino acids 340 - 390 of ME2.

Clonality

Polyclonal

Applications

ELISA, WB, IHC-P, IF

Field of Research

Homeostasis

Purification

ME2 antibody is affinity chromatography purified via peptide column.

Concentration

1 mg/mL

Form

Liquid

Storage Conditions

ME2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Observed Molecular Weight

65444 MW

Gene Name Synonym

Malic enzyme 2, NAD (+) -dependent, mitochondrial

Subcellular Location

Mitochondrion matrix.

Protein Name

Malic enzyme 2, NAD (+) -dependent, mitochondrial

Isotype

IgG

Contents

ME2 Antibody is supplied in PBS containing 0.02% sodium azide.

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