Anti-THP UMOD Antibody
Boster Bio Anti-THP UMOD Antibody catalog # A01303. Tested in WB applications. This antibody reacts with Human, Mouse.
Product Specifications
Synonyms
Uromodulin; Tamm-Horsfall urinary glycoprotein; THP; Uromodulin, secreted form; UMOD
Gene Name
UMOD
UniProt
P07911
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
Recombinant fusion protein of human UMOD (NP_001008390.1) .
Clonality
Polyclonal
Tissue Specificity
Expressed in the tubular cells of the kidney. Most abundant protein in normal urine (at protein level) . Synthesized exclusively in the kidney. Expressed exclusively by epithelial cells of the thick ascending limb of Henle's loop (TALH) and of distal convoluted tubule lumen.
Applications
WB
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Concentration
1 mg/mL
Form
Liquid
Function
Uromodulin: Functions in biogenesis and organization of the apical membrane of epithelial cells of the thick ascending limb of Henle's loop (TALH), where it promotes formation of complex filamentous gel-like structure that may play a role in the water barrier permeability (Probable) . May serve as a receptor for binding and endocytosis of cytokines (IL-1, IL-2) and TNF (PubMed:3498215) . Facilitates neutrophil migration across renal epithelia (PubMed:20798515) .
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Observed Molecular Weight
69761 MW
Applications Notes
WB: 1:500-1:2000
Gene Name Synonym
Uromodulin
Subcellular Location
Apical cell membrane
Protein Name
Uromodulin
Contents
Rabbit IgG, 1mg/mL in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
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