Anti-Lysine-specific demethylase 6A KDM6A Antibody
Boster Bio Anti-Lysine-specific demethylase 6A KDM6A Antibody catalog # A01286. Tested in WB, IHC, IF applications. This antibody reacts with Human, Mouse, Rat.
Product Specifications
Synonyms
Lysine-specific demethylase 6A;1.14.11.-
Gene Name
KDM6A
UniProt
O15550
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant protein of mouse KDM6A
Clonality
Polyclonal
Applications
WB, IHC, IF
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Concentration
1 mg/mL
Form
Liquid
Function
Histone demethylase that specifically demethylates 'Lys- 27' of histone H3, thereby playing a central role in histone code (PubMed:17851529, PubMed:17713478, PubMed:17761849) . Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-27' (PubMed:17851529, PubMed:17713478, PubMed:17761849) . Plays a central role in regulation of posterior development, by regulating HOX gene expression (PubMed:17851529) . Demethylation of 'Lys-27' of histone H3 is concomitant with methylation of 'Lys-4' of histone H3, and regulates the recruitment of the PRC1 complex and monoubiquitination of histone H2A (PubMed:17761849) . Plays a demethylase-independent role in chromatin remodeling to regulate T-box family member-dependent gene expression (By similarity) .
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Observed Molecular Weight
154177 MW
Gene Name Synonym
Lysine-specific demethylase 6A
Subcellular Location
Nucleus .
Protein Name
Lysine-specific demethylase 6A
Contents
Rabbit IgG, 1mg/mL in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
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