Anti-PDK1 Antibody
Boster Bio Anti-PDK1 Antibody catalog # A01268. Tested in WB, IHC applications. This antibody reacts with Human, Mouse, Rat.
Product Specifications
Synonyms
[Pyruvate dehydrogenase (acetyl-transferring) ] kinase isozyme 1, mitochondrial;2.7.11.2; Pyruvate dehydrogenase kinase isoform 1; PDH kinase 1; PDK1; PDHK1
Gene Name
PDK1
UniProt
Q15118
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Synthesized peptide derived from PDK1 . at AA range: 80-160
Tissue Specificity
Expressed predominantly in the heart. Detected at lower levels in liver, skeletal muscle and pancreas. .
Applications
WB, IHC
Purification
Immunogen affinity purified
Concentration
1 mg/mL
Form
Liquid
Function
Kinase that plays a key role in regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Plays an important role in cellular responses to hypoxia and is important for cell proliferation under hypoxia. Protects cells against apoptosis in response to hypoxia and oxidative stress. .
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Observed Molecular Weight
49244 MW
Gene Name Synonym
[Pyruvate dehydrogenase (acetyl-transferring) ] kinase isozyme 1, mitochondrial
Subcellular Location
Mitochondrion matrix .
Isotype
IgG
Contents
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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