Anti-IL6ST (phospho-S782) Antibody
Boster Bio Anti-IL6ST (phospho-S782) Antibody catalog # A01216S782. Tested in WB applications. This antibody reacts with Human, Mouse.
Product Specifications
Synonyms
Interleukin-6 receptor subunit beta; IL-6 receptor subunit beta; IL-6R subunit beta; IL-6R-beta; IL-6RB; CDw130; Interleukin-6 signal transducer; Membrane glycoprotein 130; gp130; Oncostatin-M receptor subunit alpha; CD130; IL6ST
Gene Name
IL6ST
UniProt
P40189
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
Synthetic phosphopeptide derived from human IL6ST around the phosphorylation site of Serine782.
Clonality
Polyclonal
Tissue Specificity
Found in all the tissues and cell lines examined (PubMed:2261637) . Expression not restricted to IL6 responsive cells (PubMed:2261637) . Expressed in blood serum (at protein level) (PubMed:24629561) .
Applications
WB
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Concentration
1 mg/mL
Form
Liquid
Function
Signal-transducing molecule. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize IL6ST for initiating signal transmission. Binding of IL6 to IL6R induces IL6ST homodimerization and formation of a high-affinity receptor complex, which activates Janus kinases (PubMed:2261637) . That causes phosphorylation of IL6ST tyrosine residues which in turn activates STAT3 (PubMed:19915009, PubMed:23294003) . Mediates signals which regulate immune response, hematopoiesis, pain control and bone metabolism (By similarity) . Has a role in embryonic development (By similarity) . Does not bind IL6 (PubMed:2261637) . Essential for survival of motor and sensory neurons and for differentiation of astrocytes (By similarity) . Required for expression of TRPA1 in nociceptive neurons (By similarity) . Required for the maintenance of PTH1R expression in the osteoblast lineage and for the stimulation of PTH-induced osteoblast differentiation (By similarity) . Required for normal trabecular bone mass and cortical bone composition (By similarity) .
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Observed Molecular Weight
103537 MW
Applications Notes
WB: 1:500-1:1000
Gene Name Synonym
Interleukin-6 receptor subunit beta
Subcellular Location
Isoform 1: Cell membrane
Protein Name
Interleukin-6 receptor subunit beta
Contents
Rabbit IgG, 1mg/mL in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
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