Anti-SIN3A Antibody
Boster Bio Anti-SIN3A Antibody catalog # A01203. Tested in WB applications. This antibody reacts with Human, Rat.
Product Specifications
Synonyms
Paired amphipathic helix protein Sin3a; Histone deacetylase complex subunit Sin3a; Transcriptional corepressor Sin3a; SIN3A
Gene Name
SIN3A
UniProt
Q96ST3
Host
Rabbit
Reactivity
Human, Rat
Immunogen
Recombinant fusion protein of human Sin3A (NP_056292.1) .
Clonality
Polyclonal
Applications
WB
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Concentration
1 mg/mL
Form
Liquid
Function
Acts as a transcriptional repressor. Corepressor for REST. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Also interacts with MXD1-MAX heterodimers to repress transcription by tethering SIN3A to DNA. Acts cooperatively with OGT to repress transcription in parallel with histone deacetylation. Involved in he control of the circadian rhythms. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex through histone deacetylation. Cooperates with FOXK1 to regulate cell cycle progression probably by repressing cell cycle inhibitor genes expression (By similarity) .
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Observed Molecular Weight
145175 MW
Applications Notes
WB: 1:500-1:2000
Gene Name Synonym
Paired amphipathic helix protein Sin3a
Subcellular Location
Nucleus
Protein Name
Paired amphipathic helix protein Sin3a
Contents
Rabbit IgG, 1mg/mL in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
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