Anti-PHO1 APOBEC3A Antibody
Boster Bio Anti-PHO1 APOBEC3A Antibody catalog # A01183. Tested in WB applications. This antibody reacts with Human, Mouse, Rat.
Product Specifications
Synonyms
DNA dC->dU-editing enzyme APOBEC-3A; A3A;3.5.4.38
Gene Name
APOBEC3A
UniProt
P31941
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Synthetic peptide, corresponding to amino acids 67-112 of Human PHO1.
Clonality
Polyclonal
Tissue Specificity
Expressed in peripheral leukocytes with higher expression in CD14-positive phagocytic cells. Highly expressed in keratinocytes and in periphery blood monocytes. Also detected in non-lymphoid tissues including lung and adipose tissues. Found at high levels in colorectal adenocarcinoma, Burkitt's lymphoma and chronic myelogenous leukemia.
Applications
WB
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Concentration
1 mg/mL
Form
Liquid
Function
DNA deaminase (cytidine deaminase) with restriction activity against viruses, foreign DNA and mobility of retrotransposons. Exhibits antiviral activity against adeno- associated virus (AAV) and human T-cell leukemia virus type 1 (HTLV-1) and may inhibit the mobility of LTR and non-LTR retrotransposons. Selectively targets single-stranded DNA and can deaminate both methylcytosine and cytosine in foreign DNA. Can induce somatic hypermutation in the nuclear and mitochondrial DNA. May also play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation.
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Observed Molecular Weight
23012 MW
Applications Notes
WB: 1:500-1:1000
Gene Name Synonym
DNA dC->dU-editing enzyme APOBEC-3A
Subcellular Location
Nucleus. Cytoplasm.
Protein Name
DNA dC->dU-editing enzyme APOBEC-3A
Contents
Rabbit IgG, 1mg/mL in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
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