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Anti-IKB Alpha (Phospho-S32) NFKBIA Antibody

Boster Bio Anti-IKB Alpha (Phospho-S32) NFKBIA Antibody catalog # A01139S32. Tested in WB, ICC applications. This antibody reacts with Human.

Product Specifications

Synonyms

NF-kappa-B inhibitor alpha; I-kappa-B-alpha; IkB-alpha; IkappaBalpha; Major histocompatibility complex enhancer-binding protein MAD3; NFKBIA; IKBA, MAD3, NFKBI

Gene Name

NFKBIA

UniProt

P25963

Host

Rabbit

Reactivity

Human

Immunogen

Synthetic phospho-peptide corresponding to residues surrounding Ser32 of human IKB alpha.

Clonality

Polyclonal

Applications

WB, ICC

Purification

ProA affinity purified

Concentration

1 mg/mL

Form

Liquid

Function

Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription.

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Observed Molecular Weight

35609 MW

Gene Name Synonym

NF-kappa-B inhibitor alpha

Subcellular Location

Cytoplasm. Nucleus. Shuttles between the nucleus and the cytoplasm by a nuclear localization signal (NLS) and a CRM1-dependent nuclear export. .

Protein Name

NF-kappa-B inhibitor alpha

Contents

Rabbit IgG, 1mg/mL in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

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