Anti-IKB Alpha NFKBIA Antibody
Boster Bio Anti-IKB Alpha NFKBIA Antibody catalog # A01139. Tested in WB, ICC/IF, IHC, IP applications. This antibody reacts with Human, Mouse, Rat.
Product Specifications
Synonyms
NF-kappa-B inhibitor alpha; I-kappa-B-alpha; IkB-alpha; IkappaBalpha; Major histocompatibility complex enhancer-binding protein MAD3; NFKBIA; IKBA, MAD3, NFKBI
Gene Name
NFKBIA
UniProt
P25963
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant protein
Clonality
Polyclonal
Applications
WB, ICC, IF, IHC, IP
Purification
ProA affinity purified
Concentration
1 mg/mL
Form
Liquid
Function
Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription.
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Observed Molecular Weight
35609 MW
Gene Name Synonym
NF-kappa-B inhibitor alpha
Subcellular Location
Cytoplasm. Nucleus. Shuttles between the nucleus and the cytoplasm by a nuclear localization signal (NLS) and a CRM1-dependent nuclear export. .
Protein Name
NF-kappa-B inhibitor alpha
Contents
Rabbit IgG, 1mg/mL in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
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