Anti-MAD1L1 Antibody
Boster Bio Anti-MAD1L1 Antibody catalog # A01137. Tested in WB, ICC/IF applications. This antibody reacts with Human.
Product Specifications
Synonyms
Mitotic spindle assembly checkpoint protein MAD1; Mitotic arrest deficient 1-like protein 1; MAD1-like protein 1; Mitotic checkpoint MAD1 protein homolog; HsMAD1; hMAD1; Tax-binding protein 181; MAD1L1; MAD1, TXBP181
Gene Name
MAD1L1
UniProt
Q9Y6D9
Host
Rabbit
Reactivity
Human
Immunogen
Recombinant fusion protein of human MAD1/MAD1/MAD1L1 (NP_001013859.1) .
Clonality
Polyclonal
Tissue Specificity
Expressed weakly at G0/G1 and highly at late S and G2/M phase.
Applications
WB, ICC, IF
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Concentration
1 mg/mL
Form
Liquid
Function
Component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. May recruit MAD2L1 to unattached kinetochores. Has a role in the correct positioning of the septum. Required for anchoring MAD2L1 to the nuclear periphery. Binds to the TERT promoter and represses telomerase expression, possibly by interfering with MYC binding.
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Observed Molecular Weight
83067 MW
Gene Name Synonym
Mitotic spindle assembly checkpoint protein MAD1
Subcellular Location
Nucleus. Chromosome, centromere, kinetochore
Protein Name
Mitotic spindle assembly checkpoint protein MAD1
Contents
Rabbit IgG, 1mg/mL in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
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