Anti-Aldh3A1 Antibody

Aldh3A1 is a member of the aldehyde dehydrogenase superfamily, a group of NAD (P) (+) -dependent enzymes that catalyze the oxidation of a wide spectrum of aliphatic and aromatic aldehydes. Aldh3A1 is highly expressed in stomach and even more strongly in cornea, representing between 5 to 50% of the water soluble protein fraction in mammalian corneas. It is thought that Aldh3A1 acts to protect the cornea from UV-induced oxidative stress by not only detoxification of reactive aldehydes by also through the direct absorbtion of UV energy. However, corneas from Aldh3A1-null mice are indistinguishable from those from wild-type mice; mice lacking both Aldh3A1 and Aldh1A1 showed increased cataract formation following UVB exposure, suggesting that Aldh1A1 may be able to compensate for the loss of Aldh3A1.

Aldh3A1 antibody was raised against a 13 amino acid synthetic peptide near the carboxy terminus of the human Aldh3A1. The immunogen is located within the last 50 amino acids of Aldh3A1.

ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde (Probable) . They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation (Probable) . Oxidizes medium and long chain aldehydes into non-toxic fatty acids (PubMed:1737758) . Preferentially oxidizes aromatic aldehyde substrates (PubMed:1737758) . Comprises about 50 percent of corneal epithelial soluble proteins (By similarity) . May play a role in preventing corneal damage caused by ultraviolet light (By similarity) .

Aldh3A1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.