Anti-Interleukin-1 receptor type 1 IL1R1 Antibody
Boster Bio Anti-Interleukin-1 receptor type 1 IL1R1 Antibody catalog # A01092. Tested in WB applications. This antibody reacts with Human, Mouse, Rat.
Product Specifications
Synonyms
Interleukin-1 receptor type 1; IL-1R-1; IL-1RT-1; IL-1RT1; CD121 antigen-like family member A; Interleukin-1 receptor alpha; IL-1R-alpha; Interleukin-1 receptor type I; p80; CD121a; Interleukin-1 receptor type 1, membrane form; mIL-1R1; mIL-1RI; Interleukin-1 receptor type 1, soluble form; sIL-1R1; sIL-1RI; IL1R1; IL1R, IL1RA, IL1RT1
Gene Name
IL1R1
UniProt
P14778
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
A synthetic peptide of human IL1R1 (NP_000868.1) .
Clonality
Polyclonal
Tissue Specificity
Expressed in T-helper cell subsets. Preferentially expressed in T-helper 1 (Th1) cells.
Applications
WB
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Concentration
1 mg/mL
Form
Liquid
Function
Receptor for IL1A, IL1B and IL1RN. After binding to interleukin-1 associates with the coreceptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Binds ligands with comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex. Involved in IL1B-mediated costimulation of IFNG production from T-helper 1 (Th1) cells (PubMed:10653850) .
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Observed Molecular Weight
65402 MW
Applications Notes
WB: 1:500-1:2000
Gene Name Synonym
Interleukin-1 receptor type 1
Subcellular Location
Membrane
Protein Name
Interleukin-1 receptor type 1
Contents
Rabbit IgG, 1mg/mL in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
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