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Anti-ATP7A (H640) Antibody

Boster Bio Anti-ATP7A (H640) Antibody catalog # A01085. Tested in IHC applications. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Synonyms

Copper-transporting ATPase 1;3.6.3.54; Copper pump 1; Menkes disease-associated protein; ATP7A; MC1, MNK

Gene Name

ATP7A

UniProt

Q04656

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide, corresponding to amino acids 620-670 of Human ATP7A.

Clonality

Polyclonal

Tissue Specificity

Found in most tissues except liver. Isoform 3 is widely expressed including in liver cell lines. Isoform 1 is expressed in fibroblasts, choriocarcinoma, colon carcinoma and neuroblastoma cell lines. Isoform 2 is expressed in fibroblasts, colon carcinoma and neuroblastoma cell lines.

Applications

IHC

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Concentration

1 mg/mL

Form

Liquid

Function

May supply copper to copper-requiring proteins within the secretory pathway, when localized in the trans-Golgi network. Under conditions of elevated extracellular copper, it relocalized to the plasma membrane where it functions in the efflux of copper from cells.

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Observed Molecular Weight

163373 MW

Applications Notes

IHC: 1:50-1:200

Gene Name Synonym

Copper-transporting ATPase 1

Subcellular Location

Golgi apparatus, trans-Golgi network membrane

Protein Name

Copper-transporting ATPase 1

Contents

Rabbit IgG, 1mg/mL in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

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