Anti-Integrin Beta 4 ITGB4 Antibody
Boster Bio Anti-Integrin Beta 4 ITGB4 Antibody catalog # A01015. Tested in WB, IHC applications. This antibody reacts with Human, Mouse.
Product Specifications
Synonyms
Integrin beta-4; GP150; CD104; ITGB4
Gene Name
ITGB4
UniProt
P16144
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
Recombinant protein
Clonality
Polyclonal
Tissue Specificity
Integrin alpha-6/beta-4 is predominantly expressed by epithelia. Isoform beta-4D is also expressed in colon and placenta. Isoform beta-4E is also expressed in epidermis, lung, duodenum, heart, spleen and stomach.
Applications
WB, IHC
Purification
ProA affinity purified
Concentration
1 mg/mL
Form
Liquid
Function
Integrin alpha-6/beta-4 is a receptor for laminin. Plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility. ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed:20682778) . ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed:22351760) . ITGA6:ITGB4 binds to IGF2 and this binding is essential for IGF2 signaling (PubMed:28873464) .
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Observed Molecular Weight
202167 MW
Gene Name Synonym
Integrin beta-4
Subcellular Location
Cell membrane; Single-pass type I membrane protein. Cell membrane; Lipid-anchor. Cell junction, hemidesmosome. Colocalizes with DST at the leading edge of migrating keratinocytes.
Protein Name
Integrin beta-4
Contents
Rabbit IgG, 1mg/mL in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
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