Anti-TWIST1 (M1) Antibody
Boster Bio Anti-TWIST1 (M1) Antibody catalog # A00980. Tested in WB applications. This antibody reacts with Human, Mouse.
Product Specifications
Synonyms
Twist-related protein 1; Class A basic helix-loop-helix protein 38; bHLHa38; H-twist; TWIST1; BHLHA38, TWIST
Gene Name
TWIST1
UniProt
Q15672
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
A synthetic peptide corresponding to amino acids 1-50 of Human TWIST1.
Clonality
Polyclonal
Tissue Specificity
Subset of mesodermal cells.
Applications
WB
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Concentration
1 mg/mL
Form
Liquid
Function
Acts as a transcriptional regulator. Inhibits myogenesis by sequestrating E proteins, inhibiting trans-activation by MEF2, and inhibiting DNA-binding by MYOD1 through physical interaction. This interaction probably involves the basic domains of both proteins. Also represses expression of proinflammatory cytokines such as TNFA and IL1B. Regulates cranial suture patterning and fusion. Activates transcription as a heterodimer with E proteins. Regulates gene expression differentially, depending on dimer composition. Homodimers induce expression of FGFR2 and POSTN while heterodimers repress FGFR2 and POSTN expression and induce THBS1 expression. Heterodimerization is also required for osteoblast differentiation. Represses the activity of the circadian transcriptional activator: NPAS2-ARNTL/BMAL1 heterodimer (By similarity) .
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Observed Molecular Weight
20954 MW
Applications Notes
WB: 1:500-1:1000
Gene Name Synonym
Twist-related protein 1
Subcellular Location
Nucleus.
Protein Name
Twist-related protein 1
Contents
Rabbit IgG, 1mg/mL in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
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