Anti-IL4R Antibody (C-term)
Boster Bio Anti-IL4R Antibody (C-term) (Catalog # A00807-3) . Tested in Flow Cytometry, WB application (s) . This antibody reacts with Human.
Product Specifications
Background
Receptor for both interleukin 4 and interleukin 13. Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammation. In certain cell types, can signal through activation of insulin receptor substrates, IRS1/IRS2.
Synonyms
Interleukin-4 receptor subunit alpha, IL-4 receptor subunit alpha, IL-4R subunit alpha, IL-4R-alpha, IL-4RA, CD124, Soluble interleukin-4 receptor subunit alpha, Soluble IL-4 receptor subunit alpha, Soluble IL-4R-alpha, sIL4Ralpha/prot, IL-4-binding protein, IL4-BP, IL4R, IL4RA
Gene Name
IL4R
UniProt
P24394
Host
Rabbit
Reactivity
Human
Immunogen
This IL4R antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 677-691 amino acids from the C-terminal region of human IL4R.
Clonality
Polyclonal
Tissue Specificity
Isoform 1 and isoform 2 are highly expressed in activated T-cells
Applications
Flow Cytometry, WB
Field of Research
Cancer, Immunology, Interleukins
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Function
Receptor for both interleukin 4 and interleukin 13. Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammation. In certain cell types, can signal through activation of insulin receptor substrates, IRS1/IRS2.
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Observed Molecular Weight
89658 Da
Subcellular Location
Cell membrane; Single-pass type I membrane protein
Isotype
Rabbit IgG
Contents
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.
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