Anti-IL-4R Alpha (G493) Antibody
Boster Bio Anti-IL-4R Alpha (G493) Antibody catalog # A00807. Tested in WB, IF applications. This antibody reacts with Human, Mouse, Rat.
Product Specifications
Synonyms
Interleukin-4 receptor subunit alpha; IL-4 receptor subunit alpha; IL-4R subunit alpha; IL-4R-alpha; IL-4RA; CD124; Soluble interleukin-4 receptor subunit alpha; Soluble IL-4 receptor subunit alpha; Soluble IL-4R-alpha; sIL4Ralpha/prot; IL-4-binding protein; IL4-BP; IL4R; IL4RA;582J2.1
Gene Name
IL4R
UniProt
P24394
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Synthetic peptide, corresponding to amino acids 460-510 of Human IL-4Rα.
Clonality
Polyclonal
Tissue Specificity
Isoform 1 and isoform 2 are highly expressed in activated T-cells.
Applications
WB, IF
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Concentration
1 mg/mL
Form
Liquid
Function
Receptor for both interleukin 4 and interleukin 13. Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammation. In certain cell types, can signal through activation of insulin receptor substrates, IRS1/IRS2.
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Observed Molecular Weight
89658 MW
Gene Name Synonym
Interleukin-4 receptor subunit alpha
Subcellular Location
Cell membrane; Single-pass type I membrane protein.
Protein Name
Interleukin-4 receptor subunit alpha
Contents
Rabbit IgG, 1mg/mL in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
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