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Anti-Nestin Antibody (S1409)

Boster Bio Anti-Nestin Antibody (S1409) (Catalog # A00806-1) . Tested in WB, IHC-P, IF, Flow Cytometry application (s) . This antibody reacts with Human.

Product Specifications

Background

Nestin is a class VI intermediate filament protein expressed predominantly in stem cells of the neural tube but absent from virtually all differentiated CNS cells. In the CNS, nestin is downregulated upon differentiation and replaced by neurofilaments. Transient expression of nestin has been postulated as a key step committing cells to the neural differentiation pathway. Nestin expression has also been observed in pancreatic hematopoietic stem cell populations.

Synonyms

Nestin, NES

Gene Name

NES

UniProt

P48681

Host

Rabbit

Reactivity

Human

Immunogen

This Nestin antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1389-1416 amino acids from human Nestin.

Clonality

Polyclonal

Tissue Specificity

CNS stem cells.

Applications

WB, IHC-P, IF, Flow Cytometry

Field of Research

Cancer, Cardiovascular, Developmental Biology, Neuroscience, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Function

Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen- stimulated proliferation of neural progenitor cells (By similarity) .

Storage Conditions

Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Observed Molecular Weight

177439 Da

Isotype

Rabbit IgG

Contents

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.

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