Anti-Smad7 Antibody
Boster Bio Anti-Smad7 Antibody catalog # A00784. Tested in WB applications. This antibody reacts with Human, Mouse, Rat.
Product Specifications
Synonyms
Mothers against decapentaplegic homolog 7; MAD homolog 7; Mothers against DPP homolog 7; Mothers against decapentaplegic homolog 8; MAD homolog 8; Mothers against DPP homolog 8; SMAD family member 7; SMAD 7; Smad7; hSMAD7; SMAD7; MADH7, MADH8
Gene Name
SMAD7
UniProt
O15105
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
A synthetic peptide corresponding to residues in Human Smad7.
Clonality
Polyclonal
Tissue Specificity
Ubiquitous with higher expression in the lung and vascular endothelium.
Applications
WB
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Concentration
1 mg/mL
Form
Liquid
Function
Antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members; has been shown to inhibit TGF-beta (Transforming growth factor) and activin signaling by associating with their receptors thus preventing SMAD2 access. Functions as an adapter to recruit SMURF2 to the TGF-beta receptor complex. Also acts by recruiting the PPP1R15A- PP1 complex to TGFBR1, which promotes its dephosphorylation. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Observed Molecular Weight
46426 MW
Applications Notes
WB: 1:500-1:1000
Gene Name Synonym
Mothers against decapentaplegic homolog 7
Subcellular Location
Nucleus
Protein Name
Mothers against decapentaplegic homolog 7
Contents
Rabbit IgG, 1mg/mL in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
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