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Anti-ELAVL1 Antibody

Boster Bio Anti-ELAVL1 Antibody (Catalog # A00736) . Tested in WB, IHC-P, Flow Cytometry application (s) . This antibody reacts with Human, Mouse.

Product Specifications

Background

ELAVL1 is involved in 3'-UTR ARE-mediated MYC stabilization. It binds avidly to the AU-rich element in FOS and IL3/interleukin-3 mRNAs. In the case of the FOS AU-rich element, HUR binds to a core element of 27 nucleotides that contain AUUUA, AUUUUA and AUUUUUA motifs.

Synonyms

ELAV-like protein 1, Hu-antigen R, HuR, ELAVL1, HUR

Gene Name

ELAVL1

UniProt

Q15717

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

This ELAVL1 antibody is generated from rabbits immunized with human ELAVL1 recombinant protein.

Clonality

Polyclonal

Tissue Specificity

Ubiquitous. Detected in brain, liver, thymus and muscle.

Applications

WB, IHC-P, Flow Cytometry

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Function

14517288182854623135896932245947862650317632515182854622351941214731398862650329180010

Storage Conditions

Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Observed Molecular Weight

36092 Da

Subcellular Location

Cytoplasm. Nucleus. Cytoplasm, Stress granule {ECO:0000250|UniProtKB:P70372}. Cytoplasm, P-body. Note=Translocates into the cytoplasm following phosphorylation by MAPKAPK2 (PubMed:14517288) . Likewise, phosphorylation by PRKCD promotes translocation from the nucleus into the cytoplasm, where it is associated with free and cytoskeleton-bound polysomes (PubMed:18285462) .Localizes to the stress granules in the presence of PLEKHN1 (By similarity) . {ECO:0000250|UniProtKB:P70372, ECO:0000269|PubMed:14517288, ECO:0000269|PubMed:18285462}

Isotype

Rabbit IgG

Contents

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.

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