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Anti-MCL1 Antibody (BH3 Domain Specific)

Boster Bio Anti-MCL1 Antibody (BH3 Domain Specific) (Catalog # A00712-1) . Tested in IHC-P, WB, Flow Cytometry application (s) . This antibody reacts with Human, Mouse, Rat.

Product Specifications

Background

The Mcl-1 protein belongs to the Bcl-2 family. Alternative splicing occurs at this locus and two transcript variants encoding distinct isoforms have been identified. The longer gene product (isoform 1) enhances cell survival by inhibiting apoptosis while the alternatively spliced shorter gene product (isoform 2) promotes apoptosis and is death-inducing.

Synonyms

Induced myeloid leukemia cell differentiation protein Mcl-1, Bcl-2-like protein 3, Bcl2-L-3, Bcl-2-related protein EAT/mcl1, mcl1/EAT, MCL1, BCL2L3

Gene Name

MCL1

UniProt

Q07820

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

This MCL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 191-226 amino acids from human MCL1.

Clonality

Polyclonal

Applications

IHC-P, WB, Flow Cytometry

Field of Research

Cancer, Cell Biology, Metabolism, Apoptosis, Mitochondria

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Function

Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis.

Storage Conditions

Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Observed Molecular Weight

37337 Da

Subcellular Location

Membrane; Single-pass membrane protein. Cytoplasm. Mitochondrion. Nucleus, nucleoplasm Note=Cytoplasmic, associated with mitochondria

Isotype

Rabbit IgG

Contents

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.

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