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Anti-ADM/Adrenomedullin Antibody

Boster Bio Anti-ADM/Adrenomedullin Antibody catalog # A00594. Tested in WB, IHC, IF, ELISA applications. This antibody reacts with Human, Rat.

Product Specifications

Synonyms

ADM; Adrenomedullin; AM; Proadrenomedullin N-20 terminal peptide; ProAM N-terminal 20 peptide; PAMP; ProAM-N20; ADM; AM

Gene Name

ADM

UniProt

P35318

Host

Rabbit

Reactivity

Human, Rat

Immunogen

The antiserum was produced against synthesized peptide derived from the Internal region of human ADM. AA range:101-150

Clonality

Polyclonal

Tissue Specificity

Highest levels found in pheochromocytoma and adrenal medulla. Also found in lung, ventricle and kidney tissues.

Applications

WB, IHC, IF, ELISA

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using a epitope-specific immunogen.

Concentration

1 mg/mL

Form

Liquid

Function

AM and PAMP are potent hypotensive and vasodilatator agents. Numerous actions have been reported most related to the physiologic control of fluid and electrolyte homeostasis. In the kidney, am is diuretic and natriuretic, and both am and pamp inhibit aldosterone secretion by direct adrenal actions. In pituitary gland, both peptides at physiologically relevant doses inhibit basal ACTH secretion. Both peptides appear to act in brain and pituitary gland to facilitate the loss of plasma volume, actions which complement their hypotensive effects in blood vessels.

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Observed Molecular Weight

20420 MW

Gene Name Synonym

ADM

Subcellular Location

Secreted.

Isotype

IgG

Contents

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

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